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KMID : 0352519810180020451
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Korea Univercity Medical Journal
1981 Volume.18 No. 2 p.451 ~ p.459
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Combined Effect and Change of Enzyme Activity due to Cd and Pb Combined Administration to rats
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Abstract
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In order to study interaction of cadmium (Cd) and lead (Pb) when exposed at the-same time, 1 mg/kg body weight of Cd and/or 4 mg/kg body weight of Pb were simultaneously injected into 78 adult rats of Sprague-Dawley Species intraperitonially every day for 10 to 60 days and their contents in liver, kidney and bone of the rats-were measured at every 10 day-interval.
The results were summarized as follows;
1. Kidney and :fiver which were the target organs of Cd were seemed to have been. damaged since from 30th day after combined injection of Cd with Pb when maximum or critical concentration was shown, whereas it was shown from 60th day after-injection of Cd only.
2. In case of Cd-Pb combined administration, concentration of Cd in bone tissue started´ increasing from 50th day after initial administration, whereas it started from 30th day after in case of injection of Cd only. It was thought that Cd contained in liver and kidney would be transported to bone tissue after decreasement of accummulation. rate in the kidney & liver.
3. The similar phenomena were also shown in case of Pb accummulation showing-
remarkable decreasement of it after 40th day of combined injection of Cd and Pb.
4. Concentration of iron in liver of rats exposed to Cd and/or Pb became lower and.
lower as time went by compared with that of control group. Degree of decreasement
was more severe in the group exposed to both of Cd and Pb at the same time.
5. Activity of LDH decreased from 10th day after the simultaneous injection of Cd with.
Pb, and it increased again at 50th day of experiment. And activity of alkaline-
phosphatase started decreasing from 20th day after exposure of Cd and Pb.
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